Medicinal Chemisry_Fourth edition_by Ashutosh Kar.zip
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Showing posts with label Medicinal chemistry. Show all posts
Showing posts with label Medicinal chemistry. Show all posts
Sunday, January 17, 2010
Wilson and Gisvols Textbook of organic, medicinal and pharmaceutical chemistry_11th edition
http://www.easy-share.com/1908309685.html
http://www.easy-share.com/1908309685.html
Monday, January 11, 2010
Wilson & Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry 11th Ed.
Oregon State Univ., Corvallis. Blends the chemical and pharmaceutical principles necessary for understanding structure-activity relationships and molecular mechanisms of drug action. Offers new information on emerging trends and advances and the challenges posed by new diseases. Features a new chapter on combinatorial chemistry.
Friday, January 8, 2010
FOYE’S PRINCIPLES OF MEDICINAL CHEMISTRY 6TH EDITION
FOYE’S PRINCIPLES OF MEDICINAL CHEMISTRY 6TH EDITION
Author(s):
Thomas L Lemke PhD
David A Williams PhD
The Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist.
A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures.
Case studies from previous editions and answers to this edition's case studies are available online at thePoint.
Friday, December 25, 2009
Introduction to medicinal chemistry
Introduction to Medicinal Chemistry
Introduction to Medicinal Chemistry: How Drugs Act and Why by: Alex Gringauz
Publisher: Wiley-VCH ISBN: 0471185450 1996-12-27 Pages: 736 DJVU 23 MB
This work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities of today's pharmacist have dictated a restructuring of the pharmacy curriculum, including individual course content. This book reflects and addresses these developments. This is a well-written work that covers most major areas of pharmaceutical research. The text is presented in a logical and concise fashion being divided into chapters based upon therapeutic topic. This makes the work very useful for teaching a course in medicinal chemistry since therapeutic areas can be separately covered without having to make use of the entire book which overall contains a tremendous amount of information. This book is a significant contribution to understanding what medicinal chemistry is and how this science is used to develop new therapeutic agents.
Basic Considerations of Drug Activity.
Mechanisms of Drug Action.
Drug Metabolism and Inactivation.
Anticancer Drugs and Their Mechanism of Action.
Analgetics and Nonsteroidal Antiinflammatory Agents.
Antimicrobial Drugs I. Antimicrobial Drugs II.
Drugs Affecting Cholinergic Mechanisms.
Drugs Affecting Adrenergic Mechanisms.
Drugs and the Cardiovascular Diseases.
Drugs and the Cardiovascular Diseases II.
Psychoactive Drugs--Chemotherapy of the Mind.
Histamine Antagonists and Local Anesthetics.
Steroids.
New Developments and New Problems.
Index.
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Principles Of Organic Medicinal Chemistry
Principles of Organic Medicinal Chemistry
The book Principles of Organic Medicinal Chemistry describes the principles and concepts of chemistry, synthetic schemes, structure activity relationships, mechanism of action and clinical uses of carbon compounds in the light of modern trends. The book covers the syllabi of B.Pharmacy and M.Pharmacy courses of all Indian Universities.
This book comprises of 22 chapters. Chapter 1 gives an introduction to medicinal chemistry, Chapter 2 explain about the basics on principles of drug action and physicochemical properties of organic medicinal, substances are elaborated in Chapter 3. The concepts of Prodrugs and Drug metabolism are summarized in Chapter 4 and Chapter 5 respectively. Chapter 6 to Chapter 22 explains chemistry, properties, mechanism of action, structure activity relationships, chemistry of newer drugs and clinical uses of various therapeutic agents. At the end of book, a set of more than 200 essays and short questions and 225 objective questions with answers are strategically designed.
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Advanced Practical Medicinal Chemistry
Advanced Practical Medicinal Chemistry
The present compendium on Advanced Practical Medicinal Chemistry is designed specifically to serve as a text-cum-reference book not only intended for the advanced undergraduate and graduate students of Pharmacy specializing in pharmaceutical chemistry but also for the bulk-drug industrial researchers and academics who work intimately with medicinal compounds. It mainly comprises of four comprehensive chapters. First chapter is entirely devoted to Safety in Chemical Laboratory, which is an absolute must for each medicinal chemist. Second chapter is on Drug Synthesis and concentrates on three vital aspects, namely : conceptualization of a synthesis, reaction variants, and stereochemistry. Third chapter exclusively deals with Performing the Reactions and entails the wide range of latest laboratory techniques used in a good chemical laboratory to facilitate synthesis of drugs.
Fourth chapter is particularly focused and earmarked to Synthesis of Medicinal Compounds, and essentially include various cardinal aspects, such as :types of chemical reactions, organic name reactions (ONRs), and selected medicinal compounds. A galaxy of eighty carefully chosen medicinal compounds have been presented in an original unique style comprising of: chemical structure, synonym (s)/chemical name(s) theory chemicals required procedure precautions recrystallization theoretical yield/practical yield physical parameters uses, and questions for viva-voce.
It is hoped that Advanced Practical Medicinal Chemistry would certainly help to bridge existing gap and fill up the long needed vacuum in the synthesis of drugs in pharmaceutical chemistry departments, academics and bulk-drug industries, and may provide the basis for meaningful productive group discussions of synthetic problems on a broader perspective.
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Burger's Medicinal Chemistry and Drug Discovery, 6th Volume set
Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set
This new sixth edition of Burger's Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development.
With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger's Medicinal Chemistry and Drug Discovery includes more than 50ew material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including:
* Proteomics
* Genomics
* Bioinformatics
* Combinatorial Chemistry
* High-Throughput Screening
* Blood Substitutes
* Allosteric Effectors as Potential Drugs
* COX Inhibitors
* Statins
* High-Throughput Pharmacology
* and More.
The new sixth edition of Burger's Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as "Medicinal Chemistry" in two volumes in 1951. Dr. Burger's research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger's contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.
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Progress in Medicinal Chemistry : Volume 29
Progress in Medicinal Chemistry : Volume 29
Hardbound. The 29th volume of the series presents yet again, an exemplary survey of a wide range of current topics in medicinal chemistry and pharmacology. Eight expert reviews emphasize the relationships between chemical structure and pharmacological activity. These detailed discussions of some of the most exciting developments in the field today, will prove of great value to future research. The book begins with a study of anti-inflammatory activities of 5-lipoxygenase inhibitors, followed by an overview of the antiarrhythmic therapeutic possibilities offered by Class III electrophysiological agents. Structures and activities of some opioid ligands are surveyed, and the investigation into pharmacologically active pyridazine derivatives is continued. Dopamine D2 receptor agonists offer exciting therapeutic potential, as do ondansetron and related 5-HT3 antagonists. The herbal origin of many modern drugs is yet again reflected in a survey.
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Medicinal Chemistry
Medicinal Chemistry
Medicinal Chemistry
Publisher: New Age International English ISBN: 9788122423057 960 pages 2007 PDF 31 Mb
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Medicinal Chemistry of Bioactive Natural Products
Medicinal Chemistry of Bioactive Natural Products
Medicinal Chemistry of Bioactive Natural Products by: Xiao-Tian Liang, Wei-Shuo Fang.(Editors)
Publisher: Wiley ISBN: 0471660071 April 2006 Pages: 460 PDF 5.5 MB
Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive natural products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.
Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.
Enhanced by examples with updated research results, the discussion covers such topics as:
* The chemistry and biology of epothilones
* Vancomycin and other glycopeptide antibiotic derivates
* Antitumor and other related activities of Taxol and its analogs
* The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)
* Huperzine A: A natural drug for the treatment of Alzheimer's disease
* The medicinal chemistry of ginkgolides from Ginkgo biloba
* Recent progress in Calophyllum coumarins as potent anti-HIV agents
* Plant-derived anti-HIV agents and analogs
* Chemical synthesis of annonaceous acetogenins and their structurally modified mimics
1 The Chemistry and Biology of Epothilones—Lead Structures for the Discovery of Improved Microtubule Inhibitors (Karl-Heinz Altmann).
2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives (Roderich D. Su¨ssmuth).
3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs (Wei-Shuo Fang, Qi-Cheng Fang, and Xiao-Tian Liang).
4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer’s Disease (Da-Yuan Zhu, Chang-Heng Tan, and Yi-Ming Li).
5 Qinghaosu (Artemisinin)—A Fantastic Antimalarial Drug from a Traditional Chinese Medicine (Ying Li, Hao Huang, and Yu-Lin Wu).
6 Progress of Studies on the Natural Cembranoids from the Soft Coral Species of Sarcophyton Genus (Yulin Li, Lizeng Peng, and Tao Zhang).
7 Medicinal Chemistry of Ginkgolides from Ginkgo biloba (Kristian Strømgaard).
8 Recent Progress in Calophyllum Coumarins as Potent Anti-HIV Agents (Lin Wang, Tao Ma, and Gang Liu).
9 Recent Progress and Prospects on Plant-Derived Anti-HIV Agents and Analogs (Donglei Yu and Kuo-Hsiung Lee).
10 Recent Progress on the Chemical Synthesis of Annonaceous Acetogenins and Their Structurally Modified Mimics (Tai-Shan Hu, Yu-Lin Wu, and Zhu-Jun Yao).
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Transporters as Targets for Drugs
Transporters as Targets for Drugs
Transporters are proteins which span the plasma membrane and regulate the traffic of small molecules in and out of the cell. Transporters play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. The majority of transporters which are actively being pursued as targets for drug discovery are CNS located and this reflects the history of the field which began with the tricyclic antidepressants (TCAs) over half a century ago. The use of transporter inhibition to regulate the synaptic concentrations of key neurotransmitters is an established approach in the discovery of psychiatric medications. This volume reviews advances in the field of transporters as targets for drug discovery in the last 10 years. The volume will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotech and academia. Following an overview chapter, seven chapters written by leading experts in their area reflect a range of topics pertinent to the transporter field. General topics include recent advances in the structural biology of transporters and its impact on potential structure based drug design and the design of ligands for Positron Emission Tomography and the importance of molecular imaging in understanding early clinical data. Medicinal chemistry approaches are described outlining the discovery of selective serotonin, noradrenaline and dopamine reuptake inhibitors, current efforts towards the discovery of mixed re-uptake inhibitors with varied ‘flavours’ of monoamine inhibition, advances in the development of inhibitors for the glycine transporter and the discovery of subtype selective EAAT inhibitors. In addition to being an interesting read, the reader will receive a critical overview of progress made in this rapidly developing field.
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Contemporary Drug Synthesis
Drug Synthesis
Contemporary Drug Synthesis by: Jie Jack Li Douglas
Publisher: Wiley-Interscience ISBN: 0471214809 2004-06-25 Pages: 240 PDF 2.7 MB
An integrated and insightful look at successful drug synthesis in today’s drug discovery market
The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug.
Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry’s most respected scientists, this timely volume:
* Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others
* Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis
* Organizes the drugs into fourteen therapeutic areas for clarity and ease of use
Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry
students.
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