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Publisher: Marcel Dekker
Number Of Pages: 496
Publication Date: 2003-08-01
Sales Rank: 2815297
ISBN / ASIN: 0824747798
EAN: 9780824747794
Binding: Hardcover
Manufacturer: Marcel Dekker
Studio: Marcel Dekker
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Fifteen chapters by researchers from around the world detail an original homogenous assay for biomolecule detection and capture through duplex colloid particles, as well as new methods for using peptides in particle aggulation. The book presents the utilization of colloids in diagnosis and therapy, with recent research results, new methodologies, and several applications. Studies reporting on the interactions (adsorption, desorption, covalent coupling, etc.) between biomolecules (nucelic acids, proteins, antibodies, peptides, viruses, etc.) are also included.
Book Description:
Colloidal Biomolecules, Biomaterials, and Biomedical Applications is an authoritative presentation of established and recent techniques promising to revolutionize the areas of biomedical diagnostics, therapeutics, pharmaceutics, and drug delivery. This exceptional book details an original homogeneous assay for biomolecule detection and capture through duplex colloid particles, as well as new methods for utilizing peptides in particle agglutination. Featuring contributions from over 30 prominent researchers, it investigates physical studies of the agglutination of sensitive latexes, and indicates benefits to drug delivery through supercritical fluid process production of polymer particles.
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Biopharmaceutics Applications in Drug Development fills this gap. This book introduces fundamental concepts, methods, and advances in the areas of dissolution, absorption, and permeability and their key applications in dosage form performance. Case studies are used to discuss the applications of biopharmaceutic strategies in the development of successful drugs, with a specific focus on the applications of biopharmaceutic strategies in the development of successful drugs. The book presents an integrated view in linking pharmaceutic to the biological consequences of drug products and leverages those for decision making in drug development.
by III, Robert O. Williams, David R. Taft, Jason T. McConville
Advanced Drug Formulation Design to Optimize Therapeutic Outcomes demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. This book discusses nanoparticle systems for cancer treatments, and also presents cutting edge immono-regulation agents for transplantation and the local targeting of drugs, especially poorly water soluble drugs to provide enhanced therapeutic outcomes. In addition, it highlights areas of therapy showing the most promise for improvement in clinical outcomes via advanced formulation design. Features Partial Table of Contents Part 1: Infectious Diseases Part 2: Oncology Part 3: Transplantation Part 4: Other Therapies Index
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Drugs, Cosmetics, Mechanisms, Methods, Fourth Edition (Drugs and the Pharmaceutical Sciences)"
Informa HealthCare 2005-07-25 ISBN: 1574448692 920 pages PDF 11 MB
Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, the fourth edition of Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methodology includes new chapters on topics currently impacting the field including chemical mixtures, in-vivo and in-vitro absorption correlations, transcutaneous immunization, and hair follicle penetration. It emphasizes drug delivery techniques such as the use of microneedles, nanosomes, liposomes, microemulsions, phonophoresis, and the enhancement of oligonucleotide drug penetration. The Journal of Applied Cosmetology said the first edition was "indispensable."
The primary focus is on the applications of the principles, paying attention to practical processes and problems. This is done both as part of the treatment of the fundamentals, where appropriate, and also in the separate sections devoted to specific kinds of industries. Throughout, the treatment is integrated, with the principles of colloid and interface science common to each dispersion type presented for each major physical property class, followed by separate treatments of features unique to emulsions, foams, or suspensions.
The first half of the book introduces the fundamental principles, introducing readers to suspension formation and stability, characterization, and flow properties, emphasizing practical aspects throughout. The following chapters discuss a wide range of industrial applications and examples, serving to emphasize the different methodologies that have been successfully applied.
Overall, the book shows how to approach making emulsions, foams, and suspensions with different useful properties, how to propagate them, and how to prevent their formation or destabilize them if necessary.
The author assumes no prior knowledge of colloid chemistry and, with its glossary of key terms, complete cross-referencing and indexing, this is a must-have for graduate and professional scientists and engineers who may encounter or use emulsions, foams, or suspensions, or combinations thereof, whether in process design, industrial production, or in related R&D fields.
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This book addresses problems and solutions of formulation and preformulation.The text deals with the pharmaceutical aspects of preformulation, not the synthetic nor the analytical aspects.
Pharmaceutical Preformulation will be of most interest to industrial and academic formulators, preformulators, universities, government, and patent litigators.
Contents
- The Innovator Company
- Patent Considerations
- Biological Equivalence and the Principle of (Patent) Equivalence
- Pharmaceutical Preformulation
- Molecular Investigation in Later Phases
- Macroscopic Property Determination in Later Phases
- Statistics and Optimization of Protocols
- Computer Programs
- Analytical Techniques
- Solubility
- Aqueous Solubility of Non-Ionized Drugs
- Solubility Determinations by RH-Relations
- Solubility in mixed solvents
- Solubility of Drug Substances which Ionize in Solution
- Ionic Strength
- Solubility Determinations when Adequate Supplies of Drug Substance are Available
- Solubility of Poorly Stable Compounds
- Effect of Surfactants
- Mixed Solvent Systems as a Formulation Aid in Solubilization
- Partition Coefficients
- Dielectric Constant and Solubility Parameters
- Solubility and pH
- Curved Van't Hoff Plots
- Preformulation Tasks in the Area of Solubility
- pH and pK
- Definition of pH
- Obtaining pK
- Approximate Relation between pKa and pK(c)
- Spectrophotometric Determination of pK
- Solubility of a Weak Electrolyte as a Function of pH
- Partition Coefficients of Weak Electrolytes
- Preformulation Tasks
- Surface Tension and Critical Micelle Concentration
- Instrument Properties
- Surface Tension
- Critical Micelle Concentration
- Effect of Temperature on CMC-Values
- Effect of Counter Ion on Surface Tension
- Effect of Temperature on Surface Tension
- General Impact of Amphiphilic
- Solution Kinetics
- Preliminary Task
- Reaction Order
- Fractional Lives
- Temperature Effects
- Effect of Reaction Mechanisms
- Calorimetric Methods
- pH Profiles and Buffer Effect
- Oxidation
- Kinetic Salt Effect
- Amphiphilic Drugs
- Optimization
- Preformulation Check Sheet
- Suspensions
- Solubility
- Rationale for Suspensions
- Taste
- Stability
- Viscosity
- Settling of Suspensions
- Sedimentation Kinetics
- Density Matching
- Particle Growth
- Rheograms
- Yield Diameter of Suspensions
- Protective Colloids
- Adsorption Isotherms
- Coascervates
- Surfactants
- Preservation and Surface Adsorption
- Dissolution of Suspensions
- Content Uniformity
- Pre-NDA and Pre-ANDA Testing
- Initial Specifications
- Test Post-NDA and Post-ANDA
- Production Problems
- Crystalline Solids
- Crystal Systems
- Drug Purification
- Crystal Habit
- Vapor Pressure of Solids
- Solubility Measurements
- Polymorphism by Solubility Measurements
- Metastable Solutions
- Differential Scanning Calorimetry (DSC)
- Preformulation Tasks
- Drug Substance Considerations
- Salt Selection
- Purifacation by Perticipation
- Purity Assessment by Means of Phase Solubility
- Differential Scanning Calorimetry (DSC)
- Eutectic Diagrams
- Preformulation Tasks
- Moisture Isotherms
- Water Adsorption
- Classifacation of Solids in Regards to Moisture
- Critical Moisture Content(RH*)
- Moisture Uptake below the Critical RH
- Automated Equipment
- Isotherms of "Soluble" Compounds
- Hydrates
- Hygroscopicity
- Solubilities from Moisture Isotherms
- Preformulation Tasks
- Nomenclature
- Principles of Dissolution
- The Noyes-Whitney Equation
- The Dissolution Rate "Constant"
- Particulate Dissolution
- Multiparticulates
- Equivalent "Diameters"
- Preformulation Tasks
- Micromeritics
- Microscopy
- Geometric Surface Areas
- Sieve Analysis
- Surface Areas
- Preformulation Tasks
- Shape Factors
- Geometric Surface Area and Rugosity
- Microscopically Determined shape Factors
- The Ridgeway-Rupp Experiments
- Shape Factors in General
- Dimensional Microscopic Shape Factors
- Fractal Geometry
- Fractal Analysis and Pharmaceutical Parameters
- Preformulation Tasks
- Physical Testing
- Pharmaceutical Equipment for Solid Dosage Forms
- Hard Shell Capsules
- Dissolution of Capsules
- Routine Task with Hard Shell Capsules
- Soft Shell Capsules
- Tablets
- Mechanical Testing of Solid Dosage Forms
- Disintegration Test
- Tablets-Dissolution
- Physical Compatibility
- Some Routine Tests
- Weight and Content Uniformity
- Apparent Density of Mixtures
- Cohesion-Repose Angles
- Sieve Analysis
- Effects of Polymorphism
- Preformulation Tasks
- Compatibility Testing
- Compatibility Test for Solid Dosage Forms
- Hydrates
- Dissolution Compatibility
- Vapor Pressure
- Aqueous Solution Compatibility
- Non-Aqueous Liquids
- Preformulation Task
- Dissolution Test Design
- In vitro Dissolution of Solid Dosage Forms
- Blood Level Equations
- In vivo Dissolution
- Calculating the Correlating in vitro Curve
- Calculating the Correlating in vitro Curve
- One Point Methods and Deconvolution
- Symbols
Published as a comprehensive four volume set, this title also includes a CD-ROM containing additional information and videos. Modern Biopharmaceuticals describes: “... an outstanding collection of articles from groundbreaking scientists, comprehensively describing the many novel ways cells are being deployed toward human good ...” James D. Watson, “DNA Codebreaker” & Nobel Prize Laureate (Physiology or Medicine, 1962) Modern Biopharmaceuticals is an essential reference work for biotechnologists, clinicians, medical doctors, pharmacists, pharmaceutical chemists, bio-chemists, molecular biologists, medicinal chemists, as well as all those working in the biotechnological and pharmaceutical industries, or medicinal institutes.
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Medical Applications of Colloids by Egon Matijevic
Publisher: Springer | Number Of Pages: 319 | Publication Date: 2008-08-12 | ISBN-10 / ASIN: 038776920X | PDF | 5 Mb
This volume deals with various colloid and surface phenomena related to medical and biomedical uses, especially in diagnostics including topics on the use of colloids in the analysis of blood, and of XPS of biosystems and biomaterials. Furthermore, the effects of uniform particles in drug formulations and release, and in the evaluation of particle transport and deposition in human airway (like in the lung) are treated in this book.
Springer; 2nd ed. edition (April 2, 2007) | ISBN:0387396829 | 228 pages | PDF | 5,1 Mb
This book gives an overview of the most recent advances in emulsion science, from the preparation to the destruction of these materials. This book is intended for a large audience, from undergraduate students to senior scientists. A progressive and didactic approach is proposed for that purpose. The concepts presented should provide a useful guidance for formulating and controlling the lifetime of emulsion at laboratory and industrial scales. For easy comprehension, the text is illustrated by more than 70 figures.
This book is a new edition of the one published in the series "Springer Tracts in Modern Physics (vol. 181)". The main difference is a more didactic approach which will allow the non-specialist reader to capture the essential concepts. We shall also incorporate the very last research results (solid-stabilized emulsions, metastability) and novel applications (Biotechnology).
Summary
The Clinical Use of Blood Handbook, provides a handy guide to the appropriate use of blood and blood products for prescribers of blood at all levels of the healthcare system. It is designed to provide a quick reference to transfusion, particularly when an urgent clinical decision is required. It summarizes key information from a more extensive module of learning material: The Clinical Use of Blood (see front page). Both the module and handbook have been prepared by an international team of clinical and blood transfusion specialists and reviewed by relevant WHO departments and critical readers from a range of specialties from all regions of the world.
The handbook introduces the principles of the appropriate use of blood and blood products and outlines the characteristics and indications for use of intravenous replacement fluids, whole blood, blood components and plasma derivatives. It provides a detailed guide to clinical transfusion procedures and the recognition and management of transfusion reactions. Comprehensive guidance is given on transfusion and alternatives to transfusion in the areas of general medicine, obstetrics, paediatrics & neonatology, surgery & anaesthesia, trauma & acute surgery, and burns. Key points, tables and algorithms are highlighted for easy reference and a comprehensive index is included.
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Microencapsulation: Methods and Industrial Applications, Second Edition (Drugs and the Pharmaceutical Sciences)
Publisher: Informa HealthCare 784 pages 2005-11-01 0824723171 PDF 4 Mb
Presenting breakthrough research pertinent to scientists in a wide range of disciplines-from medicine and biotechnology to cosmetics and pharmacy-this Second Edition provides practical approaches to complex formulation problems encountered in the development of particulate delivery systems at the micro- and nano-size level. Completely revised and expanded to represent the most up-to-date studies in the field, this guide covers advances in pulsatile delivery systems, injectable microparticulate systems, and site-specific delivery systems, as well as potential therapeutic applications of nanotechnology.
Pharmaceutical Product Development: In Vitro-In Vivo Correlation (Drugs and the Pharmaceutical Sciences)
 Publisher: Informa Healthcare; 1 editionLanguage: English ISBN: 0849338271 Paperback: 224 pages Data: February 12, 2007 Format: PDF Description: During the last two decades, the pharmaceutical industry has been under pressure to reduce development costs and the time needed to bring drugs to market in order to maximize return on investment and bring treatments to patients sooner. To meet these ends, pharmaceutical scientists working in the differing areas of pharmacy, pharmaceutics, and pharmacokinetics are collaborating to address physicochemical and biological issues in the early stages of development to avoid problems in later stages. In Vitro-In Vivo Correlation (IVIVC) is a multidisciplinary tool that has been successfully applied in testing the effectiveness of a drug substance. The only comprehensive guide available on IVIVC, this source illustrates the emerging importance of IVIVC in the drug development process, and covers the most recent advances and regulatory perspectives on the role of IVIVC in the pharmaceutical industry. Download - (1 Mb) | ||
 Publisher: CRC; 1st edition Language: English ISBN: 0824719948 Paperback: 708 pages Data: June 15, 1999 Format: DJVU Description: Explaining principles essential for the interpretation of data and understanding the real meaning of the result, this work describes carious methods and techniques used to characterize dispersions and measure their physical and chemical properties. It describes a variety of dispersions containing particles ranging from submicron sizes to aggregates and from hard particles to polymer latices. Download - (22 Mb) | ||
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